ZINC Deficiency - An Epidemic
This is an Excerpt from Dr. Zaidi's book, "Reverse Your Type 2 Diabetes Scientifically." Copyright © All rights reserved.
We are facing an Epidemic of
Zinc Deficiency with its horrendous health consequences.
Zinc is an
essential trace element that exists in all cells and is required by
thousands of chemical reactions in the body. Zinc is involved in the
synthesis, storage and secretion of insulin, as well as insulin action.
Zinc is also a strong antioxidant.
Several animal studies have shown Zinc deficiency to be
associated with high risk of Type
2 as well as Type 1 diabetes, but there are very few
In one such study (1), researchers investigated the relationship between
dietary intake of Zinc, and diabetes and coronary artery disease in 1769
rural individuals and 1806 urban individuals in
In another study (2),"Nurses' Health Study," in which 82,297 women in the
In addition to low dietary intake, Type 2 diabetics also have increased
urinary loss of Zinc if their diabetes is not controlled.
Supplementation Help Type 2 Diabetes?
In an animal study (3), researchers gave Zinc orally to Type 2
diabetic mice for 4 weeks. They observed a significant improvement in
blood glucose level as well as a reduction in insulin resistance. In
addition, Zinc treatment caused weight loss and a decrease in high blood
pressure (hypertension) in these mice. In another study (4), Zinc
supplementation was shown to alleviate diabetic peripheral neuropathy in
How about human studies? In one study (5), authors analyzed all
of the published studies in humans for the effects of Zinc
supplementation on diabetes and cholesterol. Compared to a placebo,
Zinc supplementation caused a mean
drop of 18.13mg/dl in fasting
blood glucose, 34.87mg/dl
in 2-hour post-meal blood glucose, and a 0.54% reduction in HbA1c
(Hemoglobin A1C). In
addition, Zinc supplementation caused a
mean decrease of 11.19mg/dl in LDL cholesterol. Studies also showed a
significant reduction in systolic and diastolic blood pressures after
In addition, Zinc is also important to fight off infections (such as common colds, pneumonia, diarrhea), heal wounds and prevent/treat AMD (Age-related Macular Degeneration.)
Who Is At
Risk For Zinc Deficiency?
- Diabetics, due to increased urinary losses of Zinc in urine if diabetes is uncontrolled.
- Elderly, due to decreased intake as well as absorption of Zinc. In addition, the elderly are usually on a number of medications (listed below) that can interfere with Zinc absorption.
- Vegetarians, because plant foods are low in Zinc content to begin with. In addition, Phytates in grains bind Zinc and inhibit its absorption.
- Alcohol consumption, which reduces Zinc absorption from intestines and increases its excretion in the urine.
- Chronic malabsorption conditions such as Crohn's disease, ulcerative colitis, chronic diarrhea, intestinal surgery, stomach-bypass surgery. These conditions cause a decrease in the absorption of Zinc, as well as an increase in the loss of Zinc in stools and urine.
- Drugs that can lead to Zinc deficiency include:
Thiazide diuretics: the mechanism is increased urinary losses of Zinc.
Antibiotics such as Cipro, Levaquin, tetracyclines. The mechanism is interference with intestinal absorption. Zinc can interfere with the absorption of these antibiotics. Therefore, take these antibiotics on an empty stomach to minimize this interaction.
Iron supplements can interfere with the absorption of Zinc in food. Therefore, take iron between meals, but not with meals.
- Any chronic illness such as chronic liver disease, chronic kidney disease, malignancy, sickle cell disease, etc.
- Children in poor countries due to malnutrition.
and breast-feeding women
Symptoms Of Zinc Deficiency
Zinc deficiency causes non-specific symptoms such as fatigue, loss of appetite, impaired immune function, delayed healing of wounds, diarrhea, hair loss, taste abnormalities, skin ulcers, age-related macular degeneration, delayed puberty, impotence, low testosterone and weight loss. Remember, these symptoms can occur due to many other medical conditions as well.
Zinc level in the blood is the most commonly used test to evaluate Zinc deficiency. However, blood level of Zinc does not necessarily reflects the tissue level. Therefore, Zinc deficiency may be present while the blood test may be within the normal range.
Zinc deficiency is basically a clinical diagnosis. Consult with
your doctor in this regard.
How Much Zinc?
The recommended daily dose of Zinc for adults is 11 mg for males
and 8 mg for females.
upper levels are 40 mg per day, both for males and females.
Sources Of Zinc
The best way to get your Zinc is through selecting foods which
are not only high in Zinc, but also good for your diabetes.
Oysters (cooked), Crab, Lobster
lamb, chicken and pork
wheat germ, pumpkin seeds, nuts, especially cashews.
oysters have the highest quantities of Zinc, followed by wheat germ
(roasted), beef, pumpkin seeds and cashews.
that whole-grain breads, cereals and legumes contain substances called
phytates which bind zinc and inhibit its absorption. Therefore, the best
sources of Zinc are animal based foods such as beef, chicken and
Breakfast cereals are fortified with Zinc, but these are not good for
If you cannot get enough Zinc through your diet for one reason or another, then consider Zinc supplements. Various forms are available such as Zinc gluconate, Zinc sulfate, and zinc acetate. Zinc lozenges and nasal sprays are available for "common colds." Avoid nasal sprays, as these can cause lack of smell sensation, which can be permanent.
Zinc glycinate is a chelated formulation and appear to have an excellent absorption. The label on the bottle will provide dosing information.
Too much Zinc can cause toxicity. Acute toxicity causes nausea, vomiting, diarrhea and abdominal cramping. Excess Zinc intake (more than 60 mg per day) on a chronic basis can cause copper deficiency, which can manifest as anemia and neurologic symptoms.
Zinc and Copper work in concert in your cells. Excess Zinc intake (more than 60 mg per day) on a chronic basis can cause copper deficiency, which can manifest as anemia and neurologic symptoms. Therefore, it makes sense to take a Zinc supplement that also contains Copper.
1. Singh RB1,
Niaz MA, Rastogi SS, Bajaj S, Gaoli Z, Shoumin Z. Current
zinc intake and risk of
diabetes and coronary artery disease and
factors associated with insulin resistance in rural and urban
Sun Q1, van Dam RM, Willett WC, Hu FB. Prospective study of
zinc intake and risk of type 2
diabetes in women.
Care. 2009 Apr;32(4):629-34
3. Adachi Y1,
Yoshida J, Kodera Y, Kiss T, Jakusch T, Enyedy EA, Yoshikawa Y, Sakurai
H. Oral administration of a zinc complex
improves type 2 diabetes and metabolic
syndromes. Biochem Biophys Res
Commun. 2006 Dec 8;351(1):165-70.
4. Liu F1,
Ma F, Kong G, Wu K, Deng Z, Wang H. Zinc
supplementation alleviates diabetic peripheral neuropathy by inhibiting
oxidative stress and upregulating metallothionein in peripheral nerves
of diabetic rats. Biol Trace Elem
Res. 2014 May;158(2):211-8.
5. Jayawardena R1, Ranasinghe P, Galappatthy P, Malkanthi R, Constantine G, Katulanda P. Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysis. Diabetol Metab Syndr. 2012 Apr 19;4(1):13. doi: 10.1186/1758-5996-4-13.
"Reverse Your Type 2
Excerpts from "Reverse Your Type 2 Diabetes, Scientifically."
Copyright © All rights reserved.
Copyright © All rights reserved.
Zinc as Zinc glycinate for high absorption*
Copper as Copper glycinate for high absorption*
Each bottle contains 60 Tablets
Regular Price = $ 35.95
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